Transcription factor Foxp1 regulates Foxp3 chromatin binding and coordinates regulatory T cell function
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چکیده
منابع مشابه
IFN regulatory factor-1 negatively regulates CD4+ CD25+ regulatory T cell differentiation by repressing Foxp3 expression.
Regulatory T (Treg) cells are critical in inducing and maintaining tolerance. Despite progress in understanding the basis of immune tolerance, mechanisms and molecules involved in the generation of Treg cells remain poorly understood. IFN regulatory factor (IRF)-1 is a pleiotropic transcription factor implicated in the regulation of various immune processes. In this study, we report that IRF-1 ...
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ژورنال
عنوان ژورنال: Nature Immunology
سال: 2019
ISSN: 1529-2908,1529-2916
DOI: 10.1038/s41590-018-0291-z